The Influence of Stent Design on Neointimal Hyperplasia of an Aortic Stent Covering the Visceral Arterial Ostia: An Experimental Study in Dogs Using a Self-expandable Nitinol Stent.
10.3348/jkrs.2008.58.5.469
- Author:
Yonghu YIN
1
;
Jin Wook CHUNG
;
Seung Hong CHOI
;
Kwang Gi KIM
;
Hyo Cheol KIM
;
Young Ho SO
;
Hwan Jun JAE
;
Whal LEE
;
Jae Hyung PARK
Author Information
1. Department of Radiology and Institute of Radiation Medicine SNUMRC, Seoul National University College of Medicine, Seoul, Korea. chungjw@radcom.snu.ac.kr
- Publication Type:Original Article
- Keywords:
Animals;
Aorta, abdominal;
Stents
- MeSH:
Alloys;
Animals;
Aorta;
Aorta, Abdominal;
Dogs;
Hyperplasia;
Stents
- From:Journal of the Korean Radiological Society
2008;58(5):469-474
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To assess the influence of stent design [interlacing (type A) vs. crossing method (type B)] on neointimal hyperplasia using a self-expandable nitinol stent, which crosses the side branches of the abdominal aorta. MATERIALS AND METHODS: In seven mongrel dogs, nitinol stents with type A and B intersections were placed in the abdominal aorta across the main branches: 4 Niti-Ms and 3 Niti-Ds. Two months after the stent placement, a DSA was performed for a stent patency evaluation, followed by the extraction of the aortas. The degree of neointimal formation along the wire was evaluated by calculating the area ratio of intimal hyperplasia (type A vs. B). A Student's t-test was employed to investigate the differences in the neointimal hyperplasia between blood types A and B. RESULTS: The total number of wire intersections overlain at the ostia branch ostia was 23 for type A and 36 for type B. The area ratio of the neointimal hyperplasia, for a given area, was 29.09+/-10.82% (type A) and 13.80+/-6.94% (type B) (p < 0.0001)]. Furthermore, the area ratios of the neointimal hyperplasia per area of stent-wire in the given area were 138.38+/-10.84% (type A), 87.58+/-7.36% (type B) (p = 0.0002). CONCLUSION: In conclusion the interlacing pattern vs. the crossing pattern showed a higher level of neointimal formation than the crossing pattern.
