Significance of Cytokine Levels in Neonates with Severe Fetal Distress.
- Author:
Won Joung CHOI
1
;
Jong Uk LEE
;
Chun Soo KIM
;
Sang Lak LEE
;
Joon Sik KIM
;
Tae Chan KWON
Author Information
1. Department of Pediatrics, Keimyung University School of Medicine, Daegu, Korea. lsl@dsrnc.or.kr
- Publication Type:Original Article
- Keywords:
Cytokine;
Interleukin (IL-1beta, IL-6, IL-18);
Fetal distress
- MeSH:
Cerebral Palsy;
Enzyme-Linked Immunosorbent Assay;
Fetal Blood;
Fetal Distress*;
Humans;
Infant;
Infant, Newborn*;
Interleukin-18;
Interleukin-6;
Interleukins;
Parturition;
Plasma;
Prognosis;
Prospective Studies
- From:Journal of the Korean Society of Neonatology
2004;11(1):29-34
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To determine the relation between the initial plasma cytokine response and the neurological prognosis in term infants with severe fetal distress. METHODS: Infants with severe fetal distress at birth (n=23) were studied prospectively. Cytokine concentrations were measured from umbilical cord blood at 3 and 12 hours of life by enzyme-linked immunosorbent assays for interleukin (IL)-1beta, IL-6, and IL-18. The study groups were divided into good (n=14) or poor prognostic group (n=9) according to survival and presence of cerebral palsy (CP) later and correlations with afore mentioned cytokine levels were determined. RESULTS: Cord blood IL-1beta and IL-18 concentrations were similar in both groups. However, infants with poor prognosis had significantly higher median (range) IL-6 concentration than infants with good prognosis at 3 hours [323.6 (32.6-812.8) vs. 38.4 (6.3- 322.7) pg/mL] (P=0.001), and 12 hours of life [287.1 (16.4-769.1) vs. 66.2 (8.8-757.8) pg/mL] (P<0.05). Significant higher IL-6 levels greater than 200 pg/mL were observed at 3 hours (P=0.005) and at 12 hours of life (P=0.023) for poor prognosis group. CONCLUSION: There was a significant correlation between neurologic outcome and plasma IL-6 levels. Higher concentrations of IL-6 (>200 pg/mL) may be a useful indicator of poor neurological outcome in infants with severe fetal distress.
