Therapeutic Predictor of Disodium Eromoglycate(DSCG) on Bronchial Asthma.
- Author:
Yoon Jeong KANG
1
;
Hyoung Gee KOH
;
Jong Wook SHIN
;
Seong Yong LIM
;
Jae Sun CHOI
;
Ji Hoon YOO
;
Sang Hoon KIM
;
In Won PARK
;
Byoung Whui CHOI
;
Sung Ho HUE
Author Information
1. Department of Internal Medicine, College of Medicine, Chung-Ang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Disodium cromoglycate;
Therapeutic predictor
- MeSH:
Adult;
Asthma*;
Child;
Cromolyn Sodium;
Eosinophils;
Humans;
Immunoglobulin E;
Respiratory Function Tests;
Rhinitis;
Skin Tests
- From:Korean Journal of Medicine
1997;52(1):1-6
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Although DSCG protects against the stimuli of various bronchoconstictor, such as exercise, it is not effective to all patients. There seems to be no therapeutic predictor that determines effectiveness of DSCG on bronchial asthma. Although it is commonly assumed that children with predominantly allergic asthma have a better response to DSCG therapy than adult patient, this has not been convincingly demonstrated, and even adult with late onset nonallergic asthma may benefit. In this study, we evaluated the factors that potentially influenced the ability of DSCG to reduce bronchial hyperresponsibility. METHODS: The treatment groups were sub-divide into effective group(n=14) and ineffective group(n=6) on the basis of significant improvement of followedup PC20 after long term therapy of DSCG. We compared clinical and laboratory data and pulmonary function test between two groups. RESULTS: 1) Disease durtion and pre-treatment pulmonary function (FEV1% predicted, FVC% predicted value) may play a role in determining effectiveness of DSCG on bronchial asthma(p<0.05). 2) Allergic rhinitis history seems to have been associated with effectiveness of DSCG(p<0,05). But this findings was not clearly demonstrated the association of atopic status because skin test, eosinophil count, serum IgE level were not significant difference between two groups(p>0.05). CONCLUSION: These results show that DSCG is effective in adult chronic asthma and early administration of DSCG, good pulmonary function test and allergic rhinitis history may lead to more favorable outcome.
