Clinical Features of Undifferentiated Spondyloarthropathy: Comparison with Ankylosing Spondylitis.
- Author:
Hye Soon LEE
1
;
Chan KIM
;
Hyo Sook PARK
;
Mi Kyoung LIM
;
Hong Ja KIM
;
Seung Won CHOI
;
Bin YOO
;
Hee Bom MOON
Author Information
1. Department of Medicine, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
HLA B-27;
Ankylosing spondylitis;
Undifferentiated spondyloarthropathy
- MeSH:
Age of Onset;
Arthralgia;
Classification;
Diagnosis;
HLA-B27 Antigen;
Humans;
Inflammation;
Joints;
Male;
Prevalence;
Sacroiliac Joint;
Sacroiliitis;
Spondylarthropathies*;
Spondylitis, Ankylosing*
- From:Korean Journal of Medicine
1997;52(1):42-48
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES:To investigate the clinical features of undifferentiated spondyloarthropathy among the HLA-B27 positive arthralgic patients and to compare with those of ankylosing spondylitis. METHODS: Two hundred and three HLA-B27 positive subjects among patients with arthralgia in various joints were classified according to the standard diagnostic criteria. The onset age, disease duration, numbers of involved joint, X-ray and bone scan findings were compared between patients with undifferentiated spondyloarthropathy(uSpA) and ankylosing spondylitis(AS). RESULTS: 1) The patients diseases were classified as ankylosing spondylitis(46%), undifferentiated spondyloarthropathy(29%), juvenile spondyloarthropathy(4%), reactive arthritis(3%), psoriatic spondyloarthropathy(1%) and unclassified(17%). 2) In undifferentiated spondyloarthropathy, the durations of the symptoms were shorter than ankylosing spondylitis and the male predominance is less prominent(5: 1 as compared to 17:1 in ankylosing spondylitis). 3) The numbers of involved peripheral joints and the frequency of peripheral joint inflammation were more frequent in undifferentiated spondyloarthropathy while the spinal joint symptoms including sacroiliac joint and the radiological severity grade of sacroiliitis were higher in ankylosing spondylitis. 4) There were no significant differences in bone scan uptake and ESR between undifferentiated spondyloarthropathy and ankylosing spondylitis. CONCLUSION: The prevalence of undifferentiated spondyloarthropathy was notable high in HLA-B27 posicive arthralgic patients when a new classification criteria was applied, Attention should be paid on the diagnosis and progression of this elusive and challenging clinical entity.
