A Study of Ten-Year Follow-Up for Immune Responses of Plasma Derived HB Vaccine(Hepavax-B(R)).
- Author:
Hyun Soo KIM
1
;
Sung Kyu CHOI
;
Ju Han KIM
;
Deok CHO
;
Soon Pal SUH
;
Sei Jong KIM
Author Information
1. Department of Internal Medicine, Chonnam Univeristy Medical School, Kwangju, Korea.
- Publication Type:Original Article
- Keywords:
Hepatitis B vaccine;
Immune response
- MeSH:
Adult;
Child;
Follow-Up Studies*;
Healthy Volunteers;
Hepatitis B;
Hepatitis B Surface Antigens;
Hepatitis B Vaccines;
Humans;
Immunization, Secondary;
Korea;
Plasma*;
Vaccination;
Young Adult
- From:Korean Journal of Medicine
1997;52(1):49-57
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: There are much controversy about the duration of antibody persistence, necessity and time of booster for hepatitis B vaccine(HB vaccine). The long term follow-up study is lack in Korea. Therefore this study is designed for evaluating the long-term immunogenicity of HB vaccine, necessity and time of booster vaccination. METHODS: The plasma derived HB vaccine (He-pavax-B(R)) was administered to healthy volunteers (28cases) as usual method. Secondary booster immunization was done at the 2nd year after primary vaccination in 6 cases(anti-HBs<10 mIU/ml). The serum transaminase levels, the HBsAg and anti-HBs were checked at the 9th month, 1st, 2nd, 3rd, 5th and 10th year after primary vaccination. RESULTS: 1) The positivity of anti-HBs (over 10mIU/ml) was 93%, 96%, 92% at the 3rd, 5th, 10th year respectively. In the children under 20 years old, it was 94Yo at the 3rd, 5th and 10th year without the secondary booster. 2) The good responders(anti-HBs>or=100mIU/ml) at the 9th month after primary vaccination are 21 cases (7%), low responders(anti-HBs: 10-100mIU/ml) 5 cases (18%), and non-responders(anti-HBs
