Two Cases of Metronidazole-induced Encephalopathy.
- Author:
Kook Hyun KIM
1
;
Jae Won CHOI
;
Ji Yun LEE
;
Tae Dong KIM
;
Jong Hae PAEK
;
Eun Ju LEE
;
Hyun A OH
;
Jun Hwan KIM
;
Byeong Ik JANG
;
Tae Nyeun KIM
;
Moon Kwan CHUNG
;
Heon Ju LEE
;
Woo Mok BYUN
Author Information
1. Departments of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea. HJLEE@med.yu.ac.kr
- Publication Type:Case Report ; English Abstract
- Keywords:
Metronidazole;
Metronidazole-induced encephalopathy;
MRI;
Hepatic encephalopathy
- MeSH:
Anti-Infective Agents/*adverse effects;
Brain Diseases/*chemically induced/diagnosis;
English Abstract;
Female;
Humans;
Magnetic Resonance Imaging;
Magnetic Resonance Spectroscopy;
Male;
Metronidazole/*adverse effects;
Middle Aged
- From:The Korean Journal of Gastroenterology
2005;45(3):195-200
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Metronidazole is a 5-nitroimidazole compound known as an antimicrobial agent widely used for the treatment of protozoal infection, anaerobic infection, Helicobacter pylori infection and hepatic encephalopathy. It may produce a number of neurologic side effects including peripheral neuropathy, seizure, encephalopathy, ataxic gait and dysarthritic speech. There have been ten or more reports of metronidazole-induced encephalopathy in the literatures including a few reports of brain imaging changes by magnetic resonance images (MRI). However, none of the case of metronidazole-induced encephalopathy in patients with hepatic encephalopathy has been reported yet. Recently, we experienced two cases of metronidazole-induced encephalopathy in patients with liver cirrhosis caused by chronic hepatitis B, which were diagnosed by brain MRI and MR spectroscopy. In this report, we present 2 cases of metronidazole-induced encephalopathy with MR imaging and MR spectroscopic changes including follow- up imaging performed after the discontinuation of the metronidazole with a review of the literatures.
