Correlation Between Serum Vitamin D Level and the Severity of Atopic Dermatitis Associated With Food Sensitization.
10.4168/aair.2013.5.4.207
- Author:
Seon Ah LEE
1
;
Soyoung HONG
;
Hyun Jung KIM
;
Soo Hyung LEE
;
Hye Yung YUM
Author Information
1. Medical Research Institute, Seoul Medical Center, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Atopic dermatitis;
vitamin D;
food allergy
- MeSH:
Aged;
Cholecalciferol;
Chromatography, Liquid;
Dermatitis, Atopic;
Food Hypersensitivity;
Humans;
Immunoglobulin E;
Male;
Tandem Mass Spectrometry;
Vitamin D;
Vitamin D Deficiency;
Vitamins
- From:Allergy, Asthma & Immunology Research
2013;5(4):207-210
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: A growing body of literature has linked vitamin D deficiency with allergic diseases, particularly atopic dermatitis (AD). In this study, we investigated the association between serum vitamin D status and the clinical manifestation of AD. We also developed an analytical method for the simultaneous determination of 25-hydroxy vitamin D3 (25(OH)D3), using liquid chromatography (LC) coupled with tandem mass spectrometry (MS/MS). METHODS: This study included 157 patients (79 males and 78 females) with AD, aged 4 months to 56 years. We evaluated disease severity using the SCORing Atopic Dermatitis (SCORAD) index. Serum levels of 25(OH)D3 were determined by LC coupled with MS/MS. Total IgE and specific IgE levels were assayed using the immunoCAP system. ANOVA was used for statistical evaluation. RESULTS: We found mild, moderate, and severe AD in 30 (11.1%), 87 (55.4%), and 40 (25.5%) patients, respectively. There was no significant correlation between serum levels of 25(OH)D3 and AD severity. However, among the 36 patients with food sensitization, the mean+/-SD serum levels of 25(OH)D3 were significantly higher (P<0.05) in patients with mild disease (21.2+/-5.18 ng/mL) compared with the levels in patients with moderate (17.9+/-4.02 ng/mL) or severe AD (13.3+/-5.11 ng/mL) disease. CONCLUSIONS: These results suggest that vitamin D deficiency is related to the severity of AD associated with food sensitization. Thus, these data suggest a role for vitamin D in a select group of AD patients.
