Effects of Sesame Oil on the Reproductive Parameters of Diabetes Mellitus-Induced Male Rats.
10.5534/wjmh.2013.31.2.141
- Author:
Zahra ABBASI
1
;
Seyed Reza Fatemi TABATABAEI
;
Yazdan MAZAHERI
;
Farid BARATI
;
Hasan MOROVVATI
Author Information
1. Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
- Publication Type:Original Article
- Keywords:
Rats;
Diabetes mellitus;
Spermatozoa;
Testis;
Testosterone;
Sesame oil
- MeSH:
Adult;
Animals;
Diabetes Mellitus;
Diet;
Germ Cells;
Male;
Rats;
Sesame Oil;
Sesamum;
Spermatocytes;
Spermatogonia;
Spermatozoa;
Testis;
Testosterone
- From:The World Journal of Men's Health
2013;31(2):141-149
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The purpose of the present study was to investigate the effect of sesame oil on the reproductive parameters of diabetic male Wistar rats. MATERIALS AND METHODS: The adult male rats in a split plot design were divided into normal (n=10), normal 5% (n=5; 5% sesame oil enriched diet), diabetic (Streptozocin induced diabetes; n=9), diabetic 5% (n=9; 5% sesame oil enriched diet), and diabetic 10% (n=9; 10% sesame oil enriched diet) groups. Diet supplementation continued for 56 days. RESULTS: Sesame oil supplementation did not reduce the plasma glucose concentration of rats in the diabetic groups (p>0.05). The total spermatogonia, spermatocytes, Leydig cells/tubule, and the germ cell to Sertoli cell ratio were lower in the diabetic rats than the normal ones (p<0.05), and with the exception of spermatogonia counts, these values improved by the addition of sesame oil to the diet (p<0.05). The sperm progressive motility and viability were lower in the diabetic rats (p<0.05) and sesame oil supplementation did not improve them. Incorporation of sesame oil into the diet improved the plasma testosterone concentration of the diabetic rats in a dose-dependent manner (p<0.05). CONCLUSIONS: In summary, sesame oil supplementation improved the reproductive parameters of diabetic rats at the levels of the testicular microstructure and function, but was not effective in protecting the epididymal sperm.
