Two Cases of Rhabdomyolysis Complicated with Doxylamine Overdose.
- Author:
Sun Joo CHO
1
;
Jeong Ki PARK
;
Dong Geun YEO
;
Ye Dal JEONG
;
Jung Yoon CHEO
;
Ki Sung AHN
;
Jee Hyen LEE
;
Ho Sang SOHN
Author Information
1. Department of Internal Medicine, College of Medicine, Catholic University of Taegu-Hyosung, Taegu, Korea.
- Publication Type:Case Report
- Keywords:
Doxylamine;
Rhabdomyolysis;
Acute renal failure
- MeSH:
Acute Kidney Injury;
Adolescent;
Adult;
Central Nervous System;
Creatine Kinase;
Diuresis;
Doxylamine*;
Humans;
Male;
Muscles;
Myoglobin;
Poisoning;
Rhabdomyolysis*;
Succinic Acid;
Suicide
- From:Korean Journal of Nephrology
2000;19(3):542-546
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Doxylamine succinate is common over-the-counter sleep medication that is frequently involved in accidental poisonings and suicide attempts. Doxylamine overdose is generally directed at the anticholinergic effect including autonomic,and central nervous system effect and direct cardiac toxicity. Rarely, rhabdomyolysis has been reported with doxylamine overdose. We experienced two cases of rhabdomyolysis with overdose of doxylamine in 17-year-old and 31-year-old male. They were diagnosed with high levels of creatine phosphokinase in serum, myoglobin in serum and urine, and increased radionuclide uptake of muscles in (99m)Tc-MDP bone scan. Patients recovered without any complications with hydration and diuresis. Clinicians should be aware of the possibility of rhabdomyolysis in patients with doxylamine overdose.
