Effect of pretreatment with gabapentin on withdrawal movement associated with intravenous rocuronium injection.
10.4097/kjae.2011.61.5.367
- Author:
Jin Sun YOON
1
;
Hee Jung JEON
;
Sam Soon CHO
;
Jae Do LEE
;
Kyung Oh KANG
;
Sang Wook RYU
;
Hong Seok KO
Author Information
1. Department of Anesthesiology and Pain Medicine, Seoul Veterans Hospital, Seoul, Korea. medisun74@naver.com
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Gabapentin;
Injection;
Pain;
Rocuronium;
Withdrawal movement
- MeSH:
Aged;
Amines;
Androstanols;
Anesthesia, General;
Cyclohexanecarboxylic Acids;
gamma-Aminobutyric Acid;
Humans;
Incidence
- From:Korean Journal of Anesthesiology
2011;61(5):367-371
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The major disadvantage of rocuronium is the withdrawal movement associated with its injection. The analgesic effect of perioperative gabapentin has been evaluated. We investigated the effects of gabapentin on the withdrawal movement induced by rocuronium injection. METHODS: 86 ASA physical status I or II patients, aged 18-69 years who were scheduled to undergo elective surgery with general anesthesia were enrolled. Patients were randomly allocated into two groups to receive either gabapentin 600 mg or placebo 2 hours prior to surgery. The patient's response to rocuronium injection was graded using a 4-point scale. RESULTS: The incidence of withdrawal movement after rocuronium administration was significantly lower in the gabapentin group (55.0% in the control group vs 28.6% in the gabapentin group). The number of patients with generalized response indicating severe pain, was 9 (22.5%) in the control group and 3 (7.1%) in the gabapentin group. CONCLUSIONS: Pretreatment with a single oral dose of gabapentin 600 mg reduced the incidence and severity of withdrawal movement after rocuronium administration.
