The Relationship of Insulin Resistance to High-Sensitivity C-Reactive Protein.
- Author:
Rojin PARK
1
;
Jeong Ho KIM
;
Yong Seok YUN
;
Young Duk SONG
;
Kyung Rae KIM
;
Kyung Soon SONG
;
Oh Hun KWON
;
Kap Bum HUH
Author Information
1. Department of Clinical Pathology, Yonsei University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Insulin resistance;
High-sensitivity C-reactive protein;
Type 2 diabetes mellitus;
Glucose disposal rate;
Inflammation
- MeSH:
Atherosclerosis;
C-Reactive Protein*;
Diabetes Mellitus, Type 2;
Enzyme-Linked Immunosorbent Assay;
Fibrinogen;
Glucose;
Humans;
Inflammation;
Insulin Resistance*;
Insulin*;
Male;
Plasminogen Activators;
Reference Values;
Research Personnel;
Risk Factors
- From:Korean Journal of Clinical Pathology
2001;21(6):465-470
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Insulin resistance is known as the common denominator of risk factors of atheros-clerosis as well as the major pathogenic process of type 2 diabetes mellitus (DM). Recently some investigators indicated the relationship of chronic inflammatory reaction to atherosclerosis and insulin resistance. We examined the relationship between insulin resistance and high sensitivity CRP (hs-CRP) in Koreans. METHODS: Twenty-five patients with type 2 DM and eleven healthy men were examined. Glucose disposal rate (GDR, mg/kg/min) was determined as the index of insulin resistance by the euglycemic insulin clamp test with De Fronzo method. The serum hs-CRP level was determined by Behring nephelometric assay, fibrinogen by functional assay, and plasminogen activator inhibitor-1 (PAI-1) by ELISA. We also included 81 healthy subjects to determine the reference range of hs-CRP. RESULTS: The reference range (median) of hs-CRP was 0-5.20 (0.56) mg/L. The hs-CRP concentration was not significantly different between control and DM groups. The GDR of DM (3.8+/-1.7) showed significantly decreased value compared with normal (8.4+/-1.5) group (P<0.001). In all subjects, there was no significant correlation of GDR and hs-CRP. CONCLUSTIONS: There was no significant correlation of GDR and hs-CRP. We think the interventional prospective study with anti-inflammatory drug is warranted to elucidate the independent relationship between insulin resistance and hs-CRP.
