Association between Seasonal Changes in Vitamin D and Bone Mineral Density.
- Author:
Seung Hwa CHOI
1
;
Duk Joo LEE
;
Kwang Min KIM
;
Bom Taeck KIM
Author Information
1. Department of Family Practice and Community Health, Ajou University School of Medicine, Suwon, Korea. lovesong@ajou.ac.kr
- Publication Type:Original Article
- Keywords:
Bone mineral density;
Seasonal variation;
Vitamin D
- MeSH:
Absorptiometry, Photon;
Bone Density;
Female;
Humans;
Hyperparathyroidism, Secondary;
Osteoporosis;
Radioimmunoassay;
Seasons;
Solar System;
Vitamin D;
Vitamin D Deficiency;
Vitamins
- From:The Journal of Korean Society of Menopause
2011;17(2):88-93
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVES: Vitamin D deficiency, which causes secondary hyperparathyroidism, is considered to be a major contributor to osteoporosis. Because the serum 25-hydroxyvitamin D (25-OHD) level depend on sun exposure and, varies by season, the level of serum 25-OHD in each season at which vitamin D status can lead to changes in bone mineral density (BMD) is not known. METHODS: A total of 2,878 women who underwent periodic health examinations at Ajou University Hospital were included in this study. We measured the serum 25-OHD concentrations using radioimmunoassay and BMDs using dual energy x-ray absorptiometry (DXA). The differences in serum 25-OHD levels among groups as a function of age, season, and BMD were tested by one-way ANOVA. RESULTS: The serum 25-OHD level was not different based on age, but by season, with higher levels in the summer and autumn than in the winter and spring. However, the 25-OHD level did not have a significant relationship with BMD in any season. CONCLUSION: The serum 25-OHD level represents vitamin D status at the time of testing, which is not associated with long-term changes in BMD. When the 25-OHD levels are used to make clinical decisions related to the treatment of osteoporosis, careful interpretation is required.
