Acute Adverse Reactions to Gadolinium-based Intravenous Contrast Agents for MRI : Retrospective Analysis Using Computed Reporting System.
10.13104/jksmrm.2011.15.2.139
- Author:
Moon Hyung CHOI
1
;
Joon Il CHOI
;
Seung Eun JUNG
;
Kook Jin AHN
;
Hae Giu LEE
Author Information
1. Department of Radiology, Seoul St. Mary's Hospital, The Catholic University of Korea. dumkycji@gmail.com
- Publication Type:Original Article
- Keywords:
Magnetic resonance imaging (MRI);
Contrast agents;
Adverse reaction;
Reporting system
- MeSH:
Accounting;
Administration, Intravenous;
Contrast Media;
Electronics;
Electrons;
Gadolinium DTPA;
Hospital Information Systems;
Humans;
Incidence;
Retrospective Studies
- From:Journal of the Korean Society of Magnetic Resonance in Medicine
2011;15(2):139-145
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To assess the frequency and severity of acute adverse reactions to intravenous administration of gadolinium-based contrast agents using computerized reporting system at a single large academic institution. MATERIALS AND METHODS: We assessed data from electronic hospital information system from October 2008 to December 2010. Reactions were classified as mild, moderate, or severe. We compared the frequency of adverse reactions among three contrast agents (Gd-BT-DO3A, Gd-DTPA and Gd-EOB-DTPA). RESULTS: The total number of administrated contrast agents was 33,600, and the number of administration of Gd-BT-DO3A, Gd-DTPA and Gd-EOB-DTPA were 20,824 (62%), 10,417 (31%) and 2,359 (7%), respectively. Total 39 adverse reactions were reported accounting for 0.1161% of all administrations. The incidences of adverse reactions were 0.1248% (26/39, 67%) for Gd-BT-DO3A, 0.0768% (8/39, 21%) for Gd-DTPA, and 0.2120% (5/39, 13%) for Gd-EOB-DTPA. The difference of frequencies of adverse reaction among three contrast agents was not significant. Most cases of the adverse effect were mild (35/39, 89.7%). Moderate and severe adverse reactions were encountered in two patients, respectively. CONCLUSION: Among Koreans, adverse effects were rare, and especially, moderate to severe adverse reactions were much rarer. There was no difference among the frequencies of adverse reactions caused by three different contrast agents.
