Human fibroblasts in idiopathic retroperitoneal fibrosis express HLA-DR antigens.
10.3346/jkms.1991.6.3.279
- Author:
In Chul LEE
1
Author Information
1. Department of Pathology Asan Medical Center College of Medicine, Ulsan University Seoul, Korea.
- Publication Type:Case Reports
- Keywords:
Idiopathic retroperitoneal fibrosis;
HLA-DR antigens
- MeSH:
Adult;
Aged;
MH -;
Biological Markers;
Fasciitis/pathology;
Fibroblasts/*immunology/pathology;
Granulation Tissue/pathology;
HLA-DR Antigens/*analysis;
Humans;
Male;
Middle Aged;
Retroperitoneal Fibrosis/*immunology/pathology
- From:Journal of Korean Medical Science
1991;6(3):279-283
- CountryRepublic of Korea
- Language:English
-
Abstract:
Idiopathic retroperitoneal fibrosis (IRF) is a rare human disease characterized by non-neoplastic fibroblastic proliferation associated with chronic inflammatory cells; its pathogenesis is obscure. We undertook an immunohistochemical study for the expression of HLA-DR antigens and other immune-related markers by retroperitoneal proliferating fibroblasts and inflammatory cells from 2 IRF patients. Patterns of immunoreactivity were compared with those expressed by human nodular fasciitis (NF) and granulation tissue. In IRF, most fibroblasts immunostained strongly for HLA-DR antigens, whereas fibroblasts in NF and granulation tissue did, not immunostain at all. The fibroblasts did not immunostain for interleukin 2 receptor, C3b receptor, CD-4, CD-8, or Leu-M1 in any of the tissue studied. Most macrophages and lymphocytes in IRF and NF immunostained Strangly for HLA-DR antigens. In IRF, the CD-4 and CD-8 immunostained T-lymphocytes appeared equally distributed. The expression of HLA-DR antigens by fibroblasts in IRF indicates that this rare disease may indeed be an immune-associated hypersensitivity disorder.
