Unexpected Multidrug Resistance of Methicillin-Resistant Staphylococcus aureus in Urine Samples: A Single-Center Study.
10.4111/kju.2014.55.5.349
- Author:
Andreas LUNACEK
1
;
Uwe KOENIG
;
Christof MRSTIK
;
Christian RADMAYR
;
Wolfgang HORNINGER
;
Eugen PLAS
Author Information
1. Department of Urology, Hanusch Krankenhaus, Vienna, Austria. andreas.lunacek@acmp.at
- Publication Type:Original Article
- Keywords:
Methicillin-resistant Staphylococcus aureus;
Multidrug resistance;
Urine
- MeSH:
Agar;
Amikacin;
Anti-Bacterial Agents;
Anti-Infective Agents;
Bacteria;
beta-Lactamases;
Clindamycin;
Diffusion;
Drug Resistance, Multiple*;
Erythromycin;
Gentamicins;
Humans;
Levofloxacin;
Methicillin-Resistant Staphylococcus aureus*;
Mupirocin;
Penicillin G;
Penicillins
- From:Korean Journal of Urology
2014;55(5):349-353
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Infections of methicillin-resistant Staphylococcus aureus (MRSA) are becoming an increasingly concerning clinical problem. The aim of this study was to assess the development of MRSA in urine cultures in a major public university-affiliated hospital and the therapeutical and hygiene-related possibilities for reducing resistance. MATERIALS AND METHODS: This study included 243 samples from patients diagnosed with MRSA infection over a period of 6 years. An agar diffusion test measured the effects of antimicrobial agents against bacteria grown in culture. The analyses were based on the guidelines of the Clinical and Laboratory Standards Institute. RESULTS: A regression analysis was performed, which showed 100% resistance to the following antibiotics throughout the entire testing period: carbapenem, cephalosporin (1st-4th generation), penicillin G, aminopenicillin, beta-lactamase, and isoxazolyl penicillin. However, a significant decrease in resistance was found for amikacin, gentamicin, clindamycin, levofloxacin, erythromycin, and mupirocin. CONCLUSIONS: MRSA showed a decreasing trend of antimicrobial resistance, except against carbapenem, cephalosporin (1st-4th generation), penicillin G, aminopenicillin, beta-lactamase, and isoxazolyl penicillin, for which complete resistance was observed.
