The Effect of SOD on Endothelial Function of the Rat Aorta with Renovascular Hypertension.
10.4070/kcj.1998.28.9.1600
- Author:
Joo Hee ZO
;
Young Seok CHO
;
Cheol Ho KIM
;
Byung Hee OH
;
Myoung Mook LEE
;
Young Bae PARK
;
Yun Shik CHOI
;
Young Woo LEE
- Publication Type:Original Article
- Keywords:
Endothelium;
SOD;
Renovascular hypertension;
Acetylcholine
- MeSH:
Acetylcholine;
Animals;
Aorta*;
Aorta, Abdominal;
Aorta, Thoracic;
Atherosclerosis;
Endothelium;
Female;
Humans;
Hypertension;
Hypertension, Renovascular*;
Oxidoreductases;
Phenylephrine;
Rats*;
Rats, Sprague-Dawley;
Renal Artery;
Superoxides;
Vascular Diseases
- From:Korean Circulation Journal
1998;28(9):1600-1604
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: It is well known that hypertension attenuate endothelium-dependent vasodilator response. And this finding is closely related to the development of atherosclerosis. Recently it is reported that the expression of NADPH-dependent oxidase is increased in angiotensin-induced hypertension model and superoxide (O2) produced from that might contribute to the development of vascular diseases. The possible mechanism is the degradation of endothelium-derived NO by O2. We hypothesized that SOD prevents endothelial dysfunction via prevention of the degradation of endothelium-derived NO. METHODS AND MATERIALS: We made renovascular hypertension model by constricting abdominal aorta just above the left renal artery of Sprague-Dawley female rats. The descending thoracic aorta was stuied in the organ chambers using acetylcholine as an endothelium-dependent vasodilator with or without pretreatment of SOD. RESULTS: Blood pressures of all 14 rats were significantly increased (174/123 mmHg, mean 146 mmHg). The residual tensions of the vessels precontracted by phenylephrine were similar in both groups (15.04+/-19.53 % in SOD group vs 11.84+/-18.57% in non-SOD group, p=.66). CONCLUSIONS: The endothelial dysfunctions in the rat aorta with renovascular hypertension were not improved by SOD. There is no acute effect of SOD on endothelial function in high renin/angiotensin state.
