Increment in vitamin D level and bone mineral accrual in children with vitamin D deficiency.
10.3345/kjp.2016.59.7.292
- Author:
Yashwant Kumar RAO
1
;
Tanu MIDHA
;
Satyajeet SINGH
;
Anurag BAJPAI
;
Amita TILAK
Author Information
1. Department of Pediatrics, Ganesh Shankar Vidyarthi Memorial Medical College, Kanpur, India. ykraoneo@yahoo.co.in
- Publication Type:Original Article
- Keywords:
Vitamin D;
Calcium;
Deficiency;
Bone mineral accrual;
Bone mineral density
- MeSH:
Bone Density;
Calcium;
Child*;
Cholecalciferol;
Head;
Humans;
Miners*;
Random Allocation;
Reference Values;
Vitamin D Deficiency*;
Vitamin D*;
Vitamins*
- From:Korean Journal of Pediatrics
2016;59(7):292-297
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To compare different regimens of vitamin D with respect to its serum increment levels and bone mineral accrual in vitamin D-deficient children. METHODS: Children identified as being vitamin D deficient (serum levels<20 ng/mL) were divided into 3 treatment groups by stratified block randomization (group 1, 4,000 IU/day of vitamin D3 plus 50 mg/kg/day calcium for 12 weeks; group 2, 30,000 IU/wk of vitamin D3 plus 50 mg/kg/day calcium for 12 weeks; and group 3, 300,000 IU of vitamin D3 once intramuscularly plus 50 mg/kg/day calcium). After regimen completion, each child received a maintenance dose of 400 IU/day vitamin D3 plus 50 mg/kg/day calcium. Their serum vitamin D level was measured after 3 and 12 months. Total body less head bone mineral concentration (BMC) and total body less head bone mineral density (BMD) were measured after 12 months. RESULTS: The mean increment in serum vitamin D levels from baseline to 3 months was significantly higher in group 3 than in groups 1 and 2, but the levels from 3 to 12 months were almost similar among all 3 groups. There were no significant differences among the 3 groups with respect to percentage increase of BMD and BMC. CONCLUSION: The injectable form of vitamin D was more efficacious than the oral forms in increasing the serum level to the normal range. All 3 regimens were equally effective in increasing the BMC and BMD. The 400 IU/day maintenance dose was sufficient to keep the serum level within the normal range.
