Long-Term Functional Outcome of Peripheral Neuropathy in Microscopic Polyangiitis with Poor Prognostic Factors: 3-Year Clinical Follow-up.
- Author:
Hyung Geun OH
1
;
Hyo Wook GIL
;
Ji Hye LEE
Author Information
1. Department of Neurology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea. oh906@schmc.ac.kr
- Publication Type:Case Report
- Keywords:
Vasculitis;
Neuropathy;
Outcome
- MeSH:
Aged;
Antibodies, Antineutrophil Cytoplasmic;
Biopsy;
Diagnosis;
Extremities;
Female;
Follow-Up Studies*;
Glomerulonephritis;
Humans;
Inflammation;
Kidney;
Microscopic Polyangiitis*;
Neural Conduction;
Paresthesia;
Peripheral Nervous System Diseases*;
Polyneuropathies;
Vasculitis
- From:Soonchunhyang Medical Science
2017;23(2):155-158
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Microscopic polyangiitis (MPA) is a systemic small vessel vasculitis with few or no immune deposits and no granulomatous inflammation. Peripheral neuropathy occurs in approximately 20%–30% of patients with MPA. We report a case of a 66-year-old woman who presented with paresthesia and motor weakness of the extremities and rapidly progressive glomerulonephritis. She was later diagnosed with MPA based on the findings of positive perinuclear antineutrophil cytoplasmic antibody along with findings on kidney biopsy. Nerve conduction study showed symmetric sensorimotor polyneuropathy. We followed the patient for 3 years, and she showed good functional outcome after immune-modulating therapy although Five-Factor Score more than 2 at diagnosis.
