A Case of Low dose Venlafaxine-Induced Hypertension.
- Author:
Myong Su CHOI
1
;
Sang Keun CHUNG
Author Information
1. Department of Psychiatry, Institute for Medical Sciences and Research Institute of Clinical Medicine,Chonbuk National University, Medical School, Chonju, Korea. cjcsk@moak.chonbuk.ac.kr
- Publication Type:Case Report
- Keywords:
Venlafaxine;
Hypertension;
Side effect
- MeSH:
Blood Pressure;
Depression;
Depressive Disorder, Major;
Female;
Humans;
Hypertension*;
Middle Aged;
Reference Values;
Venlafaxine Hydrochloride
- From:Korean Journal of Psychopharmacology
2001;12(1):82-86
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Venlafaxine has a dose-dependant effect on blood pressure that is clinically significant at high dose. But the cases of hypertension associated with low dose venlafaxine have been rarely reported. We experienced a case of low dose venlafaxine-induced hypertension in a 53 year-old woman with major depressive disorder who has never been diagnosed as hypertension and other medical diseases. We started venlafaxine administration at a dose of 37.5 mg/day, and on the first day of venlafaxine administration, her blood pressure was abruptly elevated. Regardless of hypertension, venlafaxine was adjusted up to 112.5 mg/day for her depressive symptoms. Hypertension was continued, but not controlled by antihypertensive medication. We thought that she had a venlafaxine-induced hypertension, so we stopped this medication. Elevated blood pressure was normalized 2 days after stopping venlafaxine administration. Her blood pressure has been within normal range without antihypertensive medication for 9 months. So we report this case with the review of the literatures on the venlafaxine-induced hypertension.
