Relationship between N-terminal pro-B-type natriuretic peptide and renal function: the effects on predicting early outcome after off-pump coronary artery bypass surgery.
10.4097/kjae.2011.61.1.35
- Author:
Youn Yi JO
1
;
Young Lan KWAK
;
Jonghoon LEE
;
Yong Seon CHOI
Author Information
1. Department of Anesthesiology and Pain Medicine, Gachon University of Medicine and Science Gil Medical Center, Incheon, Korea.
- Publication Type:Original Article
- Keywords:
NT-proBNP;
OPCAB;
Renal function
- MeSH:
Atrial Fibrillation;
Coronary Artery Bypass, Off-Pump;
Glomerular Filtration Rate;
Humans;
Myocardial Infarction;
Natriuretic Peptide, Brain;
Peptide Fragments;
Plasma;
Postoperative Complications;
Sensitivity and Specificity;
Thoracic Surgery;
Ventilators, Mechanical;
Ventricular Dysfunction
- From:Korean Journal of Anesthesiology
2011;61(1):35-41
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Plasma levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) provide useful prognostic predictors in patients after cardiac surgery. However, predictive accuracy of NT-proBNP levels has varied significantly according to renal dysfunction. The purpose of this study was to assess whether preoperative NT-proBNP levels could be used as predictors of early postoperative outcomes on the basis of renal function in patients undergoing off-pump coronary artery bypass surgery (OPCAB). METHODS: In 219 patients undergoing elective OPCAB, NT-proBNP and an estimated glomerular filtration rate (eGFR) were assessed preoperatively. All patients were divided into 3 groups according to tertiles of eGFR: the first (eGFR > or = 90 ml/min/1.73 m2), the second (90 ml/min/1.73 m2 > eGFR > or = 72 ml/min/1.73 m2) and the third tertile group (eGFR < 72 ml/min/1.73 m2). End point was the composite of early postoperative complications defined as myocardial infarction, new onset atrial fibrillation, ventricular dysfunction, prolonged mechanical ventilator care (> 48 hr), prolonged ICU stay (> or = 3 days), and in hospital mortality. RESULTS: There was no difference in early postoperative complications among groups. A preoperative NT-proBNP level of 228 pg/ml and 302 pg/ml (sensitivity 70%, specificity 67%, P < 0.001 and sensitivity 73%, specificity 63%, P = 0.001, respectively) were optimal cut-off values predicting complicated early postoperative course in second and third tertile group, respectively. CONCLUSIONS: Preoperative NT-proBNP levels seem to be predictive of early postoperative complications in patients with eGFR < 90 ml/min/1.73 m2 undergoing OPCAB.
