Prognostic significance of E-cadherin/catenin complex expression in gastric cancer.
10.3346/jkms.2000.15.6.655
- Author:
Young Eun JOO
1
;
Chang Soo PARK
;
Hyun Soo KIM
;
Sung Kyu CHOI
;
Jong Sun REW
;
Sei Jong KIM
Author Information
1. Department of Internal Medicine, Chonnam National University Medical School, Kwangju, Korea. mareejb@netian.com
- Publication Type:Original Article
- Keywords:
Cadherins;
Cytoskeletal Proteins;
Stomach Neoplasms;
Immunohistochemistry;
Neoplasm Staging;
Pronosis;
Survival Analysis
- MeSH:
Adult;
Aged;
Cadherins/biosynthesis*;
Cytoskeletal Proteins/biosynthesis*;
Female;
Human;
Male;
Middle Age;
Prognosis;
Stomach Neoplasms/pathology;
Stomach Neoplasms/metabolism*;
Survival Analysis;
Tumor Markers, Biological/biosynthesis*
- From:Journal of Korean Medical Science
2000;15(6):655-666
- CountryRepublic of Korea
- Language:English
-
Abstract:
Abnormal expression of E-cadherin/catenin complex in cancer has been associated with poor differentiation and acquisition of invasiveness, suggesting a possible role of this protein as an invasion suppressor. In this study, we conducted an immunohistochemical investigation of all components of the E-cadherin/catenin complex in 65 gastric cancer patients. Abnormal expression of E-cadherin and, alpha- and gamma-catenin occurred more frequently in diffuse than in intestinal type of gastric cancer, and correlated with poor differentiation. Abnormal expression of E-cadherin and beta-catenin correlated with poor survival. Abnormal expression of all four components of the complex was associated with poorly differentiated and diffuse-type carcinoma, and poor survival. In the multivariate analysis, abnormal expression of the E-cadherin/catenin complex was not an independent prognostic factor. These results suggest that the E-cadherin/catenin complex may be a useful marker of differentiation and prognosis in gastric cancer. Further studies are warranted to clarify the impact of the E-cadherin/catenin complex on prognostic factor of gastric cancer.
