Glutathione S-transferase Gene Polymorphisms and Systemic Lupus Erythematosus.
- Author:
Tae Young KANG
1
;
Ahmed EL-SOHEMY
;
Marilyn C CORNELIS
;
Chung Il JOUNG
;
Hye Soon LEE
;
Wan Sik UHM
;
Tae Hwan KIM
;
Jae Bum JUN
;
Dae Hyun YOO
;
Think You KIM
;
Sang Cheol BAE
Author Information
1. The Hospital for Rheumatic Diseases, Hanyang University College of Medicine, Seoul, Korea. scbae@hanyang.ac.kr
- Publication Type:Original Article
- Keywords:
Glutathione S-transferase (GST) polymorphism;
Systemic lupus erythematosus (SLE);
Anti SS-A (Ro) antibody;
Anti SS-B (La) antibody
- MeSH:
Antibodies;
Exanthema;
Genotype;
Glutathione Transferase*;
Glutathione*;
Heterozygote;
Humans;
Immunodiffusion;
Lupus Erythematosus, Systemic*;
Multiplex Polymerase Chain Reaction;
Nephritis;
Psychotic Disorders;
Rheumatology
- From:The Journal of the Korean Rheumatism Association
2003;10(3):234-242
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To determine whether GSTM1, GSTT1 and GSTP1 polymorphisms are associated with susceptibility or disease manifestations in patients with SLE. METHODS: Two hundred eighty-six SLE patients who fulfilled the American College of Rheumatology (ACR) criteria were compared with 271 cases of age and sex matched controls to examine association between GST genotypes and susceptibility to SLE. The effect of genotype on SLE manifestations was assessed using the comparison of ACR diagnostic criteria. GST gene polymorphisms were determined by a multiplex polymerase chain reaction and antibodies to SS-A and SS-B were determined by double immunodiffusion. RESULTS: No association was found in the comparison of GSTM1 null, GSTT1 null, GSTP1 Ile105--
