Diagnostic p53 expression in gastric endoscopic mucosal resection.
10.3346/jkms.1999.14.4.412
- Author:
Jeong Hee CHO
1
;
Im Hwan ROE
;
Young Joo JIN
Author Information
1. Department of Pathology, College of Medicine, Dankook University, Chunan, Korea. jhcho@anseo.dankook.ac.kr
- Publication Type:Original Article
- Keywords:
Protein p53;
Immunohistochemistry;
Surgical procedure, endoscopic, mucosal resection;
Adenoma, gastric;
Early gastric carcinoma
- MeSH:
Adenocarcinoma/surgery;
Adenocarcinoma/pathology;
Adenoma/surgery*;
Adenoma/pathology*;
Endoscopy*;
Gastric Mucosa/metabolism;
Gastric Mucosa/chemistry;
Human;
Immunoenzyme Techniques;
Protein p53/diagnostic use*;
Protein p53/biosynthesis;
Protein p53/analysis;
Stomach Neoplasms/surgery*;
Stomach Neoplasms/pathology*;
Tumor Markers, Biological
- From:Journal of Korean Medical Science
1999;14(4):412-416
- CountryRepublic of Korea
- Language:English
-
Abstract:
Endoscopic mucosal resection (EMR) has been standardized for the treatment of intestinal type of intramucosal gastric carcinomas, and careful histological examination of the resected specimen is important for further treatment. To evaluate the diagnostic utility of p53 expression in gastric EMR samples, using immunohistochemical staining, we examined 24 gastric carcinomas (22 intestinal types and two diffuse types) and 20 adenomas removed by EMR. Intestinal type of adenocarcinomas revealed strong p53 expression in 13 cases (59%), weak in four cases (18%), and negative in five cases (23%). Resection margins of 11 carcinomas were involved in the carcinoma cells, which showed the same p53 expression pattern with main carcinoma cells. Squeezed carcinoma cells, remaining in resection margins, were definitely identified by strong p53 expression in seven cases of which the main tumor strongly expressed p53. Microscopic in situ carcinoma could be easily detected in p53 immunostaining. Multifocal involvement and submucosal invasion of carcinomas could be demarcated easily and definitely by strong p53 expression of carcinoma cells. All adenomas showed diffuse weak p53 expression. The difference of p53 expression (p< 0.001) could be used as a differential diagnosis between adenomas and carcinomas. According to these results, we propose that for careful histological examination in hospital diagnosis, both histological evaluation and p53 immunostaining are important diagnostic parameters in EMR samples of the intestinal type of gastric carcinomas.
