A Case of Gemcitabine and Cisplatin Associated Posterior Reversible Encephalopathy Syndrome.
- Author:
Eun Jin KWON
1
;
Se Won KIM
;
Kwang Ki KIM
;
Hyung Suk SEO
;
Do Yeun KIM
Author Information
1. Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea. smdkdy@hanmail.net
- Publication Type:Case Report
- Keywords:
Cisplatin;
Gemcitabine;
Posterior reversible encephalopathy syndrome (PRES)
- MeSH:
Brain;
Cisplatin;
Deoxycytidine;
Dizziness;
Female;
Follow-Up Studies;
Gallbladder Neoplasms;
Headache;
Humans;
Middle Aged;
Parietal Lobe;
Phenytoin;
Seizures
- From:Cancer Research and Treatment
2009;41(1):53-55
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 58-year-old female receiving gemcitabine and cisplatin chemotherapy for stage IV gallbladder cancer developed the clinicoradiologic syndrome, posterior reversible encephalopathy syndrome (PRES). Just before the 4th gemcitabine chemotherapy cycle, she was admitted to the hospital with complaints of headache, dizziness, and generalized tonic-clonic seizures. A MRI was performed on the day when the seizure developed, and the findings showed patchy cortical and subcortical T2 hyperintensity without enhancement that involved both occipital and parietal lobes. Phenytoin loading and maintenance was started for prevention of recurrent seizures, which was successful. The follow-up brain MRI obtained 10 days after the seizure attack showed completely resolved radiologic findings. After the MRI findings revealed complete resolution, phenytoin maintenance was stopped. Even with discontinuation of phenytoin, she had no seizures or other clinical manifestations.
