No Effect on Body Dissatisfaction of an Interaction between 5-HTTLPR Genotype and Neuroticism in a Young Adult Korean Population.
10.9758/cpn.2014.12.3.229
- Author:
Seung Keun WANG
1
;
Young Ho LEE
;
Jeong Lan KIM
;
Ik Seung CHEE
Author Information
1. Department of Psychiatry, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea. ischee@cnu.ac.kr
- Publication Type:Original Article
- Keywords:
5-HTTLPR;
Body dissatisfaction;
Neuroticism;
Self-esteem
- MeSH:
Body Dysmorphic Disorders;
Genotype*;
Humans;
Serotonin Plasma Membrane Transport Proteins;
Young Adult*
- From:Clinical Psychopharmacology and Neuroscience
2014;12(3):229-234
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: Many studies suggest an association between the serotonin transporter gene-linked polymorphic region (5-HTTLPR) and anxiety-related personality traits (e.g., neuroticism) in healthy subjects. This study investigated the interaction of 5-HTTLPR genotype on body dissatisfaction by neuroticism and to evaluate the interaction of 5-HTTLPR genotype on self-esteem by body dissatisfaction in a young adult Korean population. METHODS: Two hundred and eighty three subjects were included in this study. The Eysenck Personality Questionnaire-Korean version was used to evaluate neuroticism, the Body Dysmorphic Disorder Examination-Self Report (BDDE-SR)-Korean version was used to evaluate body dissatisfaction, and the Self-Esteem Scale (SES)-Korean version was used to evaluate self-esteem. The 5-HTTLPR genotype by neuroticism (high : low) interaction was assessed according to the total BDDE-SR score, and 5-HTTLPR genotype by BDDE-SR (high : low) interaction was assessed according to the total SES score. RESULTS: The analysis of 5-HTTLPR genotype and neuroticism (high : low) with respect to body dissatisfaction showed no main effects of genotype whereas neuroticism did influence the BDDE-SR score and no interaction of the genotype with neuroticism. The analysis of 5-HTTLPR genotype and BDDE-SR (high : low) with respect to self-esteem score showed no main effects of genotype whereas BDDE-SR did influence the self-esteem score and no interaction of the genotype with body dissatisfaction. CONCLUSION: These results suggest that an interaction between 5-HTTPLR genotype and neuroticism does not affect body dissatisfaction and an interaction between 5-HTTPLR genotype and body dissatisfaction does not affect self-esteem in a young adult Korean population.
