Effect of suction blister fluid and IFN-gamma on HLA-A,B,C and HLA-DR espression in cultures human melanocytes.
- Author:
Ai Young LEE
;
Yoo Shin LEE
- Publication Type:Original Article
- Keywords:
HLA-A;
H;
C;
FILA-DR;
IFN-r;
melanocyte
- MeSH:
Blister*;
HLA-A Antigens;
HLA-DR Antigens*;
Humans*;
Keratinocytes;
Melanocytes*;
Suction*;
Transplants;
Vitiligo
- From:Korean Journal of Dermatology
1991;29(2):151-154
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
HLA-A, B, C and HLA-DR are very important in the regulation of immune response and of transplant success or failure, but there have been a few reports about F3I A expression in melanocyt.es, a minor population of cpidermal cells. In the treatment of stable or segmental vitiligo, allogeneic melanocytes graft could t)e potentially useful if rejection does not. occur. The aim of this study was to examine the expression of HI.A-A, B, C and HI.A-DR in cultured hurnan melanocytes with and without. stimulation by INF-r and suction blister fliid. All strains of cultured me- lanocytes expressed HLA-A, B, C regardless of stmulation, but HLA-DR was expressed only following stimulation of INI-r. HLA expression in me]anocytes appears to be similar to that in keratinocytes.
