Hormonal Regulation of Hematopoietic Stem Cells and Their Niche: A Focus on Estrogen.
10.15283/ijsc.2015.8.1.18
- Author:
Hye Ryeon HEO
1
;
Li CHEN
;
Borim AN
;
Kye Seong KIM
;
Junfeng JI
;
Seok Ho HONG
Author Information
1. Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Korea. shhong@kangwon.ac.kr
- Publication Type:Review
- Keywords:
Estrogen;
Hematopoiesis;
Niche;
Stem cells
- MeSH:
Adult;
Cell Cycle;
Estrogens*;
Female;
Hematopoiesis;
Hematopoietic Stem Cells*;
Hematopoietic System;
Humans;
Megakaryocyte-Erythroid Progenitor Cells;
Pluripotent Stem Cells;
Pregnancy;
Stem Cell Niche;
Stem Cells
- From:International Journal of Stem Cells
2015;8(1):18-23
- CountryRepublic of Korea
- Language:English
-
Abstract:
Self-renewal and differentiation are hallmarks of stem cells and controlled by various intrinsic and extrinsic factors. Increasing evidence indicates that estrogen (E2), the primary female sex hormone, is involved in regulating the proliferation and lineage commitment of adult and pluripotent stem cells as well as modulating the stem cell niche. Thus, a detailed understanding of the role of E2 in behavior of stem cells may help to improve their therapeutic potential. Recently, it has been reported that E2 promotes cell cycle activity of hematopoietic stem and progenitor cells and induces them to megakaryocyte-erythroid progenitors during pregnancy. This study paves the way towards a previously unexplored endocrine mechanism that controls stem cell behavior. In this review, we will focus on the scientific findings regarding the regulatory effects of E2 on the hematopoietic system including its microenvironment.
