Regulation of Stem Cell Fate by ROS-mediated Alteration of Metabolism.
10.15283/ijsc.2015.8.1.24
- Author:
Jung Min RYU
1
;
Hyun Jik LEE
;
Young Hyun JUNG
;
Ki Hoon LEE
;
Dah Ihm KIM
;
Jeong Yeon KIM
;
So Hee KO
;
Gee Euhn CHOI
;
Ing Ing CHAI
;
Eun Ju SONG
;
Ji Young OH
;
Sei Jung LEE
;
Ho Jae HAN
Author Information
1. Department of Veterinary Physiology, College of Veterinary Medicine and Research Institute for Veterinary Science, and BK21 PLUS Creative Veterinary Research Center, Seoul National University, Seoul, Korea. hjhan@snu.ac.kr
- Publication Type:Review
- Keywords:
Reactive oxygen species;
Metabolism;
Glucose;
Amino acid;
Fatty acid;
Stem cell fate
- MeSH:
Adult Stem Cells;
Cues;
Energy Metabolism;
Glucose;
Homeostasis;
Metabolism*;
Oxygen;
Reactive Oxygen Species;
Stem Cells*
- From:International Journal of Stem Cells
2015;8(1):24-35
- CountryRepublic of Korea
- Language:English
-
Abstract:
Stem cells have attracted much attention due to their distinct features that support infinite self-renewal and differentiation into the cellular derivatives of three lineages. Recent studies have suggested that many stem cells both embryonic and adult stem cells reside in a specialized niche defined by hypoxic condition. In this respect, distinguishing functional differences arising from the oxygen concentration is important in understanding the nature of stem cells and in controlling stem cell fate for therapeutic purposes. ROS act as cellular signaling molecules involved in the propagation of signaling and the translation of environmental cues into cellular responses to maintain cellular homeostasis, which is mediated by the coordination of various cellular processes, and to adapt cellular activity to available bioenergetic sources. Thus, in this review, we describe the physiological role of ROS in stem cell fate and its effect on the metabolic regulation of stem cells.
