Indocyanine Green Angiographic Findings of Obscure Choroidal Abnormalities in Neurofibromatosis.
10.3341/kjo.2012.26.3.230
- Author:
Yong Soo BYUN
1
;
Young Hoon PARK
Author Information
1. Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea. nuntangi5@gmail.com
- Publication Type:Case Reports
- Keywords:
Choroid;
Choroidal neurofibroma;
Indocyanine green angiography;
Neurofibromatoses
- MeSH:
Child;
Choroid/*pathology;
Choroid Diseases/*diagnosis/etiology;
Coloring Agents/diagnostic use;
Diagnosis, Differential;
Female;
Fluorescein Angiography;
Follow-Up Studies;
Fundus Oculi;
Humans;
Indocyanine Green/*diagnostic use;
Male;
Middle Aged;
Neurofibromatosis 1/*complications/diagnosis
- From:Korean Journal of Ophthalmology
2012;26(3):230-234
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report two cases of choroidal neurofibromatosis, detected with the aid of indocyanine green angiography (ICGA) in patients with neurofibromatosis (NF)-1, otherwise having obscure findings based on ophthalmoscopy and fluoresceine angiography (FA). In case 1, the ophthalmoscopic exam showed diffuse bright or yellowish patched areas with irregular and blunt borders at the posterior pole. The FA showed multiple hyperfluorescent areas at the posterior pole in the early phase, which then showed more hyperfluorescence without leakage or extent in the late phase. The ICGA showed diffuse hypofluorescent areas in both the early and late phases, and the deep choroidal vessels were also visible. In case 2, the fundus showed no abnormal findings, and the FA showed weakly hypofluorescent areas with indefinite borders in both eyes. With the ICGA, these areas were more hypofluorescent and had clear borders. Choroidal involvement in NF-1 seems to occur more than expected. In selected cases, ICGA is a useful tool to be utilized when an ocular examination is conducted in a patient that has no definite findings based on the ophthalmoscope, B-scan, or FA tests.
