The clinicopathological relevance for the expression of cyclin E, CDK2, and p27 in endometrial carcinoma.
- Author:
Yun Ji BAEK
1
;
Hye In CHONG
;
Ho Jin JANG
;
Dong Soo SUH
;
Man Soo YOON
;
Kyung Un CHOI
Author Information
1. Department of Obstetrics & Gynecology, School of Medicine, Pusan National University Hospital, Busan, Korea. msyoon@pusan.ac.kr
- Publication Type:Original Article
- Keywords:
Cyclin E;
CDK;
p27;
Endometrial carcinoma
- MeSH:
Cyclin E;
Cyclins;
Endometrial Neoplasms;
Estrogens;
Female;
Humans;
Hysterectomy;
Lymph Nodes;
Neoplasm Metastasis;
Retrospective Studies
- From:Korean Journal of Obstetrics and Gynecology
2008;51(10):1112-1120
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The aim of this study was to evaluate the clinicopathological relevance for the expression of cyclin E, CDK2 and p27 in endometrial carcinoma. METHODS: With a retrospective review, slide samples (n=71) were analyzed. All patients had been treated with hysterectomy from January 1998 to December 2006. The expression of cyclin E, CDK2 and p27 were analyzed using immunohistochemical staining. RESULTS: Of 71 cases, the positive expression was cyclin E; 28 cases (39.4%), CDK2; 29 cases (40.8%). The expression of cyclin E showed positive correlation with lymph node metastasis (P=0.033) and estrogen receptor. The expression of CDK2 showed positive correlation with estrogen receptor (P=0.000). The negative expression of p27 was 42 cases (59.2%) and showed no correlation with other clinicopathological factors. Cyclin E overexpression with loss of p27 expression showed positive correlation with advanced stage (P=0.002), lymphovascular invasion (P=0.030) and lymph node metastasis (P=0.002). CONCLUSION: Cyclin E overexpression with loss of p27 expression could be an useful negative prognostic factors for endometrial carcinoma.
