Association between Insulin Resistance and Benign Prostatic Hyperplasia in Healthy Middle-aged Korean Men.
10.15384/kjhp.2015.15.4.202
- Author:
Heeseung SON
1
;
Byungseong SUH
;
Soogeun KIM
;
Junpyo MYONG
;
Youil SHON
;
Heeyun KIM
;
Hanseur JEONG
Author Information
1. Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, Medical Center of Sungkyunkwan University School of Medicine, Seoul, Korea. byungseong.suh@samsung.com
- Publication Type:Original Article
- Keywords:
Insulin resistance;
Benign prostatic hyperplasia;
Middle-aged
- MeSH:
Alcohol Drinking;
Body Mass Index;
Cholesterol, HDL;
Cholesterol, LDL;
Cross-Sectional Studies;
Humans;
Insulin Resistance*;
Insulin*;
Logistic Models;
Male;
Meat;
Odds Ratio;
Prevalence;
Prostatic Hyperplasia*;
Risk Factors;
Smoke;
Smoking;
Triglycerides;
Ultrasonography
- From:Korean Journal of Health Promotion
2015;15(4):202-208
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: We examined the association between insulin resistance assessed by homeostatic model assessment-insulin resistance (HOMA-IR) and benign prostatic hyperplasia (BPH) in healthy middle-aged male subjects. METHODS: A cross-sectional study included 1,727 male subjects, aged 40-59 year, free of medication history for BPH who received a transrectal ultrasonography and completed a structured questionnaire in 2011. Multiple logistic regression analysis was performed to evaluate the relationships of HOMA-IR with BPH across the tertile of HOMA-IR. RESULTS: The prevalence of BPH was 24.4% (421 out of 1,727). It was increased across HOMA-IR tertiles in crude and age-adjusted models. In a multivariable-adjusted model after adjusting potential confounders such as age, body mass index (BMI), triglyceride, high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), alcohol consumption, smoking, exercise and meat consumption, odds ratios (95% confidence intervals, CIs) of BPH for 2nd tertile and 3rd tertile compared to 1st tertile were 1.76 (1.31-2.35), and 1.83 (1.34-2.48), respectively. CONCLUSIONS: In middle-aged, healthy men, higher HOMA-IR was significantly associated with higher prevalence of BPH, supporting insulin resistance as an independent risk factor for BPH.
