A Case of Type IIa Hyperlipoproteinemia and Coronary Artery Disease Associated with Xanthoma Tendinosum.
- Author:
Chan Woo LEE
1
;
Seung Joo SIM
;
Ki Hoon SONG
;
Ki Ho KIM
Author Information
1. Department of Dermatology, Dong-A University, College of Medicine, Pusan, Korea. imman44@hanmail.net
- Publication Type:Case Report
- Keywords:
Hyperlipoproteinemia;
Xanthoma tendinosum;
Atherosclerosis
- MeSH:
Achilles Tendon;
Angina, Unstable;
Atherosclerosis;
Cholesterol;
Coronary Artery Disease*;
Coronary Vessels*;
Dermis;
Electrophoresis;
Foot;
Giant Cells;
Hand;
Heart Failure;
Histiocytes;
Humans;
Hyperlipoproteinemia Type II*;
Hyperlipoproteinemias;
Lipoproteins;
Male;
Middle Aged;
Xanthomatosis*
- From:Korean Journal of Dermatology
2003;41(11):1541-1543
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of type IIa hyperlipoproteinemia with xanthoma tendinosum associated with coronary artery disease in a 51 year-old male. Multiple hard nodules appeared firstly on both achilles tendon area 30 years ago and the lesions gradually spread to the dorsa of hands and feet. On past history, he had been diagnosed as unstable angina with atherosclerosis of three vessels in coronary arteries, 2 years ago. His family history revealed nothing contributory. Serum lipid profile including lipoprotein electrophoresis showed an increase in total cholesterol and LDL-cholesterol with increased beta-lipoprotein fraction, which suggested type IIa hyperlipoproteinemia. Histopathologic finding of a nodule from the dorsum of right hand showed many foamy histiocytes and cholesterol clefts in the dermis. Most of the xanthoma cells were mononuclear, but many Touton type giant cells were seen also. He died suddenly of heart failure with unstable angina.
