Association of Temporal Lobe Atrophy and Psychosis in Patients with Alzheimer's Disease.
- Author:
Je Hyun SOHN
1
;
Young Min LEE
;
Je Min PARK
;
Byung Dae LEE
;
Eun Soo MOON
;
Hee Jeong JEONG
;
Soo Yeon KIM
;
Kang Yoon LEE
;
Ji Hoon KIM
;
Young In CHUNG
Author Information
1. Department of Psychiatry, Pusan National University Hospital, Busan, Korea. psyleekr@naver.com
- Publication Type:Original Article
- Keywords:
Alzheimer's disease;
Psychosis;
Grey matter volume;
Temporal lobe
- MeSH:
Alzheimer Disease*;
Atrophy*;
Busan;
Dementia;
Education;
Gray Matter;
Hippocampus;
Humans;
Korea;
Magnetic Resonance Imaging;
Memory;
Psychotic Disorders*;
Temporal Lobe*
- From:Journal of Korean Geriatric Psychiatry
2017;21(2):87-91
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The purpose of this study is to investigate the difference on regional volume in temporal lobe between Alzheimer's disease patients with psychosis (AD+P) and Alzheimer's disease patients without psychosis (AD-P). METHODS: Altogether, 24 AD+P and 25 AD-P matched age, gender, and clinical dementia rating sum of box (CDR-SOB) were include from a Memory impairment clinics of Pusan National University Hospital in Korea. AD+P were diagnosed according to Jeste and Finkel's proposed diagnostic criteria for psychosis of Alzheimer's disease. Grey matter volume of temporal lobe was measured with 3-tesla magnetic resonance imaging and freesufer analysis. Analysis of variance was used to investigate the association between temporal lobe and AD+P after controlling age, gender, education years, CDR-SOB and total intracranial volume. RESULTS: We found an association between AD+P and reduced grey matter volume in total temporal lobe as well as in specific temporal regions such as left middle temporal lobe, left inferior temporal lobe, both hippocampus and both fusiform. CONCLUSION: Our findings suggest that AD+P are associated with reduced grey matter volume of temporal lobe.
