Association of p53 Expression with Metabolic Features of Stage I Non-Small Cell Lung Cancer.
10.4046/trd.2011.71.6.417
- Author:
Shin Myung KANG
1
;
Won Jung KOH
;
Gee Young SUH
;
Man Pyo CHUNG
;
Joungho HAN
;
Hojoong KIM
;
O Jung KWON
;
Sang Won UM
Author Information
1. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University, School of Medicine, Seoul, Korea. sangwonum@skku.edu
- Publication Type:Original Article
- Keywords:
Tumor Suppressor Protein p53;
Necrosis;
Positron-Emission Tomography;
Carcinoma, Non-Small-Cell Lung
- MeSH:
Biomarkers;
Carcinoma, Non-Small-Cell Lung;
Electrons;
Medical Records;
Necrosis;
Oxidative Phosphorylation;
Positron-Emission Tomography;
Retrospective Studies;
Stress, Physiological;
Tumor Suppressor Protein p53
- From:Tuberculosis and Respiratory Diseases
2011;71(6):417-424
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Recent evidences have revealed metabolic functions of p53 in cancer cells; adaptation or survival to metabolic stress and metabolic shift toward oxidative phosphorylation. However, further studies in clinical setting are needed. We investigated whether p53 protein expression, as a surrogate marker for loss of p53 function, is associated with metabolic features of stage I non-small cell lung cancer (NSCLC), focusing on tumor necrosis and maximal standardized uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography. METHODS: Clinical information was obtained from retrospective review of medical records. p53 expression was assessed by immunohistochemical staining. RESULTS: p53 protein expression was detected in 112 (46%) of 241 NSCLC cases included in this study. p53 expression was independently associated with the presence of necrosis (odds ratio [OR], 2.316; 95% confidence interval [CI], 1.215~4.416; p=0.011). Non-adenocarcinoma histology (OR, 8.049; 95% CI, 4.072~15.911; p<0.001) and poorly differentiation (OR, 6.474; 95% CI, 2.998~13.979; p<0.001) were also independently associated with the presence of necrosis. However, p53 expression was not a significant factor for SUVmax. CONCLUSION: p53 protein expression is independently associated with the presence of necrosis, but not SUVmax.
