Prognostic Value of Preoperative Positron Emission Tomography-Computed Tomography in Surgically Resected Stage I and II Non-Small Cell Lung Cancer.
10.4046/trd.2011.71.6.425
- Author:
Sung Heon SONG
1
;
Jang Won SOHN
;
Hyun Jung KWAK
;
Sa Il KIM
;
Sang Heon KIM
;
Tae Hyung KIM
;
Ho Joo YOON
;
Dong Ho SHIN
;
Yoon Young CHOI
;
Sung Soo PARK
Author Information
1. Division of Pulmonology, Cheju Halla General Hospital, Jeju, Korea.
- Publication Type:Original Article
- Keywords:
Carcinoma, Non-Small Cell Lung;
Positron-Emission Tomography;
Prognosis
- MeSH:
Body Weight;
Carcinoma, Non-Small-Cell Lung;
Electrons;
Humans;
Multivariate Analysis;
Positron-Emission Tomography;
Prognosis;
Recurrence;
Retrospective Studies;
ROC Curve
- From:Tuberculosis and Respiratory Diseases
2011;71(6):425-430
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: High 2-[18F] fluoro-2-deoxy-D-glucose (FDG) uptake on positron emission tomography-computed tomography (PET-CT) is a prognostic factor for poor survival in non-small cell lung cancer (NSCLC), especially in Stage I. We determined whether the high FDG uptake value of a primary tumor was associated with recurrence and death in patients with resected Stage I and Stage II NSCLC. METHODS: We identified consecutive patients who underwent complete surgical resection for Stage I and II NSCLC between 2006 and 2009, who had preoperative PET-CT, and reviewed clinical records retrospectively. FDG uptake was measured as the maximal standardized uptake value (SUVmax) for body weight. Patients were divided into two groups based on SUVmax: (i) above or (ii) below the cut-off value (SUVmax=5.9) determined by a receiver operating characteristic (ROC) curve. RESULTS: Of 57 patients who were enrolled consecutively, 32 (56%) had Stage I NSCLC and 25 (44%) had Stage II. The 5-year recurrence-free survival (RFS) for patients with high (> or =5.9) and low (<5.9) SUVmax were 31% and 57%, respectively (p=0.014). The 5-year overall survival (OS) rates were 39% and 60%, respectively (p=0.029). In univariate analyses, SUVmax (p=0.014), T staging (p=0.025), and differentiation of tumor tissue (p=0.034) were significantly associated with RFS. But, multivariate analyses did not show that SUVmax was an independently significant factor for RFS (p=0.180). CONCLUSION: High FDG uptake on PET-CT is not an independent prognostic factor for poor outcomes (disease recurrence in patients with resected Stage I and II NSCLC).
