A Case of Acute Eosinophilic Pneumonia after Hematopoietic Stem Cell Transplantation.
10.4046/trd.2011.71.6.459
- Author:
Hwan Sung PARK
1
;
Tae Jin OK
;
You Jae KIM
;
Guang Un KIM
;
Soeun PARK
;
Jihyun AN
;
Yun Ku KIM
;
Jae Ho JEONG
;
Su Jeong KIM
;
Yumi LEE
;
Ho Su LEE
;
Bo Hyoung KANG
;
Ga Hee KIM
;
Dae Young KIM
;
Woo Sung KIM
;
Dong Soon KIM
;
Jin Woo SONG
Author Information
1. Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Pulmonary Eosinophilia;
Hematopoietic Stem Cell Transplantation;
Graft vs Host Disease
- MeSH:
Anoxia;
Bronchoalveolar Lavage Fluid;
Cough;
Dyspnea;
Eosinophilia;
Eosinophils;
Fever;
Graft vs Host Disease;
Hematopoietic Stem Cell Transplantation;
Hematopoietic Stem Cells;
Humans;
Leukemia, Myeloid, Acute;
Middle Aged;
Pulmonary Eosinophilia;
Skin;
Thorax
- From:Tuberculosis and Respiratory Diseases
2011;71(6):459-463
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Pulmonary complications occur in 40~60% of patients who receive hematopoietic stem cell transplantation (HSCT) and are a source of substantial morbidity and mortality. Acute eosinophilic pneumonia (AEP) is an uncommon, non-infectious pulmonary complication occurring in HSCT recipients. We now report the case of a 52-year-old man with AEP who was treated with allogenic HSCT due to acute myeloid leukemia. He complained of fever, cough and dyspnea 390 days after allogenic HSCT. He also had skin and hepatic graft versus host disease (GVHD). Hypoxemia, diffuse pulmonary infiltrates on a chest x-ray and eosinophilia in bronchoalveolar lavage fluid were also noted in several tests. His symptoms, pulmonary infiltrates, hepatic dysfunction and skin lesions rapidly improved after treatment with corticosteroid therapy. Our case supports the idea that AEP is a late phase non-infectious pulmonary complication and one of the manifestations of chronic GVHD.
