Efficacy of Biodegradable Microneedle Patches on Periorbital Wrinkles.
- Author:
Jihun PARK
1
;
Jimyung SEO
;
Jung U SHIN
;
Do Hyeon JEONG
;
Jung Dong KIM
;
Kwang Hoon LEE
Author Information
1. Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Seoul, Korea. kwanglee@yuhs.ac
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Epidermal growth factor;
Hyaluronic acid;
Microneedle patch;
Periorbital wrinkles
- MeSH:
Double-Blind Method;
Epidermal Growth Factor;
Follow-Up Studies;
Humans;
Hyaluronic Acid;
Patient Satisfaction;
Skin
- From:Korean Journal of Dermatology
2014;52(9):597-607
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Biodegradable microneedle technology is a recently developed method to deliver medical and pharmaceutical medications into the skin, and is expected to yield better treatment results than topical application methods. OBJECTIVE: To evaluate the efficacy of hyaluronic acid (HA)-based microneedle patches and epidermal growth factor (EGF)-containing microneedle patches on periorbital wrinkle improvement. METHODS: A 20-week randomized, double-blind study was performed. Twenty-five Korean patients with periorbital wrinkles and a wrinkle severity rating scale (WSRS) score above 2 were enrolled into the study. The patients completed the study using the two different types of patches on each side of the designated periorbital wrinkles area every other day for 8 weeks. Patients were requested for an additional 12-week follow up. Wrinkle improvements were assessed by WSRS score, subjective patient satisfaction score, and imaging analysis using the visiometer, corneometer, cutometer, and mexameter, respectively (Courage&Khazaka, Cologne, Germany). RESULTS: Both the HA-based microneedle patch and EGF-containing HA-based microneedle patch had positive effects on WSRS score, patient satisfaction levels, and corneometer result with statistically significant differences. No significant side effects were noticed. CONCLUSION: With respect to efficacy, no statistical difference between the two groups were noted, indicating that the anti-wrinkle effects of the microneedle patch may solely be due to the HA rather than the EGF.
