Giant Acral Melanoma on the Left Thumb of a Korean Patient.
- Author:
Jae Hwan KIM
1
;
Se Yeong JEONG
;
Jae Bin SHIN
;
Ki Woong RO
;
Soo Hong SEO
;
Sang Wook SON
;
Il Hwan KIM
Author Information
- Publication Type:Case Report
- Keywords: Bone invasion; Interferon-alpha-2a; Lymph node metastasis; Melanoma
- MeSH: Asian Continental Ancestry Group; Extremities; Female; Humans; Lymph Nodes; Melanoma; Middle Aged; Nails; Neoplasm Metastasis; Thumb
- From:Annals of Dermatology 2009;21(2):171-173
- CountryRepublic of Korea
- Language:English
- Abstract: The acral regions of the limbs of Asians are predisposed to develop malignant melanoma, but giant-sized acral melanoma has not been previously reported in the Asian population. Giant-sized melanoma implies aggressive tumor invasion and so it is more difficult to achieve a therapeutic cure. A 56-year-old woman presented with a giant acral melanoma of the left thumb with concomitant bone destruction and axillary lymph node metastasis. The initial lesion was a subungual black macule on the left thumb that had grown into a giant 7.0*4.0*3.5 cm-sized melanoma over a 3 year period. The left thumb was amputated and the axillary lymph nodes were completely dissected. During the ensuing 3 months, she underwent adjuvant treatment with interferon-alpha-2a. The interesting feature of this case is that the large melanoma mass of this patient, which was accompanied with adjacent bone destruction and lymph node metastasis, had developed rapidly from a small black macule in the nail matrix, and this black macule was suspected to be a subungual melanoma.
