Genetic and Epigenetic Marker-Based DNA Test of Stool Is a Promising Approach for Colorectal Cancer Screening.
10.3349/ymj.2009.50.3.331
- Author:
Sung Whan AN
1
;
Nam Kyu KIM
;
Hyun Cheol CHUNG
Author Information
1. Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul, Korea. sungwhan@genomictree.com
- Publication Type:Review ; Research Support, Non-U.S. Gov't
- Keywords:
Colorectal cancer screening;
stool DNA;
genetic and epigenetic alterations
- MeSH:
Colorectal Neoplasms/*diagnosis/*genetics;
Epigenesis, Genetic/*genetics;
*Feces;
Genetic Markers/*genetics;
Tumor Markers, Biological/genetics
- From:Yonsei Medical Journal
2009;50(3):331-334
- CountryRepublic of Korea
- Language:English
-
Abstract:
Colorectal cancer (CRC) is one of the most common malignancies and leading cause of cancer-related deaths in the world. However, it may be treated effectively by surgical removal of the cancerous tissue if detected at early stages. Conventional tools for screening CRC are either invasive or inaccurate. Therefore, there is an urgent need to develop a reliable screening tools for CRC to significantly reduce its morbidity. In this regard, a novel DNA markers-based detection in stool is emerging as a promising approach.
