Metallo-beta-Lactamase-Producing Pseudomonas spp. in Korea: High Prevalence of Isolates with VIM-2 Type and Emergence of Isolates with IMP-1 Type.
10.3349/ymj.2009.50.3.335
- Author:
Kyungwon LEE
1
;
Ae Ja PARK
;
Moon Yeun KIM
;
Hee Joo LEE
;
Ji Hyun CHO
;
Jung Oak KANG
;
Dongeun YONG
;
Yunsop CHONG
Author Information
1. Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea. whonetkor@yuhs.ac
- Publication Type:Original Article
- Keywords:
IMP-1;
IMP-6;
VIM-2;
metallo-beta-lactamase;
Korea
- MeSH:
Anti-Bacterial Agents/pharmacology;
Electrophoresis, Gel, Pulsed-Field;
Humans;
Imipenem/pharmacology;
Korea;
Polymerase Chain Reaction;
Pseudomonas Infections/*microbiology;
Pseudomonas aeruginosa/drug effects/genetics/*metabolism;
beta-Lactamases/genetics/*metabolism
- From:Yonsei Medical Journal
2009;50(3):335-339
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Two Korean nationwide studies showed that metallo-beta-lactamases (MBLs)-producing-Pseudomonas spp. are not rare. The aim of this study was to assess the trends of MBL-producing isolates among imipenem-resistant isolates of Pseudomonas spp. MATERIALS AND METHODS: Imipenem-resistant clinical isolates were collected from 23 hospitals and one commercial laboratory participating in the KONSAR program in 2005. Polymerase chain reaction (PCR) was used to detect MBL genes. RESULTS: Alleles of MBL genes were detected in 10.8% of 415 Pseudomonas aeruginosa and 66.7% of 12 P. putida isolates from 18 of 24 hospitals/laboratory. Among the 14 IMP-1-like and 39 VIM-2-like MBLs, emergence of IMP-6 was detected for the first time. CONCLUSION: Prevalence of MBL-producing P. aeruginosa has not significantly increased, but IMP-6 emerged in P. aeruginosa.
