Urinary nephrin: A new predictive marker for pregnancies with preeclampsia and small-for-gestational age infants.
- Author:
Ga Young YANG
1
;
Kyung A LEE
;
Mi Hye PARK
;
Hye Sook PARK
;
Eun Hee HA
;
Sun Hee CHUN
;
Young Ju KIM
Author Information
- Publication Type:Original Article
- Keywords: Nephrin; Small-for-gestational age; Preeclampsia; Urine; Early marker
- MeSH: Creatinine; Enzyme-Linked Immunosorbent Assay; Female; Humans; Infant; Membrane Proteins; Pre-Eclampsia; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Sensitivity and Specificity
- From:Obstetrics & Gynecology Science 2013;56(1):22-28
- CountryRepublic of Korea
- Language:English
- Abstract: OBJECTIVE: The objective of this study was to determine the differences in urinary nephrin among controls, gravidas with preeclampsia (PE), and small-for-gestational age (SGA) infants. We also determined whether or not maternal urinary concentrations of nephrin are associated with the subsequent development of PE and SGA infants. METHODS: We analyzed maternal urinary levels of nephrin in women who were normal controls (n=50), women who were delivered SGA infants (n=40), and gravidas with PE (n=33) in the first, second and third trimesters. Urinary nephrin concentrations were measured with nephrin enzyme-linked immunosorbent assay kits. RESULTS: The levels of urinary nephrin were higher in gravida developing preeclampsia or SGA than in controls after adjusting serum creatinine (P<0.05 for both). Maternal urine concentrations of nephrin were higher in pregnancies complicated by SGA and PE in the third trimester (P<0.05), and also higher in pregnancies complicated by SGA in the first trimester (P<0.05). The sensitivity and specificity of nephrin in predicting SGA from normal pregnancies were 67% and 89% in the first trimester, 60% and 79% in the second trimester, and 80% and 84% in the third trimester, respectively. The sensitivity and specificity of nephrin in predicting PE from normal pregnancies were 67% and 83% in the first trimester and 73% and 79% in the third trimester, respectively. CONCLUSION: We suggest that urinary nephrin can be used as an early marker in pregnancies at risk for developing PE and SGA infants.
