Feasibility of Endoscopic Endonasal Approach for Recurrent Pituitary Adenomas after Microscopic Trans-Sphenoidal Approach.
10.3340/jkns.2013.54.4.317
- Author:
Joo Min HWANG
1
;
Yong Hwy KIM
;
Jin Wook KIM
;
Dong Gyu KIM
;
Hee Won JUNG
;
Young Seob CHUNG
Author Information
1. Department of Neurosurgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Endoscopy;
Revision surgery;
Pituitary adenoma
- MeSH:
Anti-Bacterial Agents;
Endoscopy;
Follow-Up Studies;
Humans;
Pituitary Neoplasms*;
Retrospective Studies;
Tumor Burden;
Vision, Ocular
- From:Journal of Korean Neurosurgical Society
2013;54(4):317-322
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: The surgical approach for recurrent pituitary adenoma after trans-sphenoidal approach (TSA) is challenging. We report the outcomes of the endoscopic TSA for recurrent pituitary adenoma after microscopic TSA. METHODS: From February 2010 to February 2013, endoscopic TSA was performed for removal of 30 recurrent pituitary adenomas after microscopic TSA. Twenty-seven (90%) patients had a clinically non-functioning pituitary adenoma. Twenty-four (80%) patients suffered from a visual disturbance related to tumor growth. The clinical features and surgical outcomes were retrospectively analyzed for the ophthalmological, endocrinological, and oncological aspects. RESULTS: The mean tumor volume was 11.7 cm3, and gross total resection was achieved in 50% of patients. The volumetric analysis based on the postoperative MR showed that the mean extent of resection rates were 90%. Vision was improved in 19 (79%) of 24 patients with visual symptoms, and endocrinological cure was achieved in all of three functioning pituitary adenomas; however, the post-operative follow-up endocrinological examination revealed a new endocrinological deficit in one patient. Two patients required antibiotics management for post-operative meningitis. CONCLUSION: The endoscopic TSA can be an effective treatment option for recurrent pituitary adenoma after microscopic TSA with acceptable outcome.
