A case of fulminant type 1 diabetes mellitus.
- Author:
Sang Youl RHEE
1
;
Suk CHON
;
Gwanpyo KOH
;
Seungjoon OH
;
Jeong Taek WOO
;
Jin Woo KIM
;
Young Seol KIM
Author Information
1. Department of Endocrinology and Metabolism, School of Medicine, Kyung Hee University, Seoul, Korea. orqwic@chol.com
- Publication Type:Case Report
- Keywords:
Diabetes mellitus;
Type 1
- MeSH:
Acidosis;
Acute Kidney Injury;
Adult;
Antibodies;
Autoimmunity;
Blood Glucose;
Diabetes Mellitus;
Diabetes Mellitus, Type 1*;
Diabetic Ketoacidosis;
Glutamate Decarboxylase;
Humans;
Insulin;
Islets of Langerhans;
Male
- From:Korean Journal of Medicine
2006;70(3):342-346
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A novel subtype of type 1B diabetes with rapid onset and no evidence of autoimmunity has been recently proposed as fulminant type 1 diabetes. The pathogenesis of fulminant type 1 diabetes has not been fully understood. We report a case of fulminant type 1 diabetes with diabetic ketoacidosis. A 31-year-old male was referred to our hospital because of high plasma glucose level and acidosis. Laboratory findings were rendering a diagnostic picture of diabetic ketoacidosis with acute renal insufficiency. While there was high plasma glucose, normal HbA1c and other laboratory findings suggested a very recent onset of diabetes mellitus. A test to detect antibodies to islet cell antigen IA-2 was negative, but those of glutamic acid decarboxylase (GAD) was weakly positive. The patient successfully recovered without any serious complication after fluid and insulin based management.
