The Features and Prognoses in Organophosphate Intoxication according to Age.
10.4235/jkgs.2013.17.4.198
- Author:
Seung Wook LIM
1
;
Seung Min PARK
;
Young Hwan LEE
;
Won Woong LEE
;
Ji Yun AHN
;
You Dong SOHN
;
Hee Cheol AHN
;
Hyun KIM
Author Information
1. Department of Emergency Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea. aukawa@hallym.or.kr
- Publication Type:Original Article
- Keywords:
Cholinesterases;
Aged;
Organophosphate poisoning
- MeSH:
Adult;
Aged;
Central Nervous System;
Cholinesterases;
Emergencies;
Humans;
Mortality;
Organophosphate Poisoning;
Plasma;
Prognosis*;
Retrospective Studies;
Shock;
Vital Signs
- From:Journal of the Korean Geriatrics Society
2013;17(4):198-204
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The purpose of this study was to identify the factors that influence mortality in organophosphate intoxication and the differences between the elderly (> or =65 years) and younger adults (18-64 years) looking at vital sign, length of admission, cholinesterase activity, complications, and prognosis. METHODS: All patients visiting one Emergency Department (ED) with organophophate intoxication between January 2000 and December 2011 were reviewed retrospectively. We divided the patients into two groups, geriatric adults (> or = 65 years) and nongeriatric adults (18-64 years). RESULTS: During the study period, 155 patients (45 patients, > or =65 years; 110 patients, 18-64 years) presented to the ED with organophosphate intoxication. Thirty-six elderly patients (80.0%) vs. 63 younger adult patients (57.3%) were intubated endotracheally, with the analysis showing a clear distinction between the two groups (p=0.026). Twenty-two elderly patients (48.9%) vs. 23 younger adult patients (20.9%) went into shock, displaying a significant gap (p=0.008). Thirtyfive elderly patients (81.4%) vs. 62 younger adult patients (59.0%) developed respiratory complications and 20 elderly patients (46.5%) vs. 19 younger adult patients (18.1%) developed central nervous system complications, with obvious differences seen in each of the comparison at (p=0.031) and (p=0.005), respectively. Comparing plasma cholinesterase levels at 1st, 3rd, 5th, 10th, 15th, and 20th days, the rate of increase was faster in the younger adults (p=0.022). CONCLUSION: With organophosphate intoxication, elderly patients tended to be intubated endotracheally, went into shock, developed central nervous system complications, were more severe, and showed a slower increase in cholinesterase level.
