Clinicopathologic Significance of Gastric and Intestinal Phenotypic Marker Expression in Gastric Carcinomas.
10.3904/kjim.2005.20.3.191
- Author:
Gwang Ha KIM
1
;
Geun Am SONG
;
Do Youn PARK
;
Dong Hyun LEE
;
Tae Oh KIM
;
Seong Hun LEE
;
Jeong HEO
;
Dae Hwan KANG
;
Mong CHO
Author Information
1. Department of Internal Medicine, Pusan National University College of Medicine, Busan, Korea. doc0224@chol.com
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Gastric cancer;
Immunohistochemistry;
Phenotype;
Prognosis
- MeSH:
Tumor Markers, Biological/genetics;
Stomach Neoplasms/genetics/immunology/*pathology;
Prognosis;
*Phenotype;
Middle Aged;
Male;
Intestinal Neoplasms/genetics/immunology/*pathology;
Immunohistochemistry;
Humans;
Female;
Carcinoma/genetics/immunology/*pathology;
Antibodies, Neoplasm;
Antibodies, Monoclonal
- From:The Korean Journal of Internal Medicine
2005;20(3):191-197
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: It is well known that both gastric and intestinal phenotypic cell markers are expressed in gastric cancers. This study was aimed at investigating the correlation between gastric and intestinal phenotypic marker expression patterns of tumors and the clinicopathologic characteristics of gastric carcinomas. METHODS: We evaluated phenotypic marker expression by immunohistochemical staining with monoclonal antibodies. All tumors were classified as gastric (G), gastric and intestinal mixed (GI), intestinal (I), or null (N) phenotype. RESULTS: The tumors were phenotypically divided into G-phenotype tumors (33.2%), GI-phenotype tumors (25.7%), I-phenotype tumors (26.8%), and N-phenotype tumors (14.3%). N-phenotype tumors were associated with more corporeal location than GI- and I-phenotype tumors (p=0.009 and p=0.007, respectively), a larger size than I-phenotype tumors (p=0.007), a higher proportion of advanced gastric cancers than G-, GI-, and I-phenotype tumors (p=0.003, p< 0.001, and p< 0.001, respectively), more perineural invasion than G-, GI-, and I-phenotype tumors (p=0.076, p=0.003, and p=0.003, respectively), and more lymph node metastasis than GI-phenotype tumors (p=0.017). I-phenotype tumors were associated with a higher proportion of intestinal-type tumors than G-, GI-, and N-phenotype tumors (p< 0.001, p=0.011, and p< 0.001, respectively). CONCLUSION: Our results indicate that the gastric and intestinal phenotypic marker expression pattern of tumors is prognostically useful for patients with gastric carcinoma.
