Lack of Association of Glutathione S-transferase P1 Ile105Val Polymorphism with Aspirin-Intolerant Asthma.
10.3904/kjim.2005.20.3.232
- Author:
Jung Mi OH
1
;
Seung Hyun KIM
;
Chang Hee SUH
;
Dong Ho NAHM
;
Hae Sim PARK
;
Young Mok LEE
;
June Hyuk LEE
;
Choon Sik PARK
;
Hyung Doo SHIN
Author Information
1. Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea.
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Aspirin-intolerant asthma;
Hyperresponsiveness;
Glutathione-S-transferase
- MeSH:
Polymorphism, Restriction Fragment Length;
Polymorphism, Genetic;
Male;
Korea;
Isoenzymes/*genetics;
Humans;
Glutathione S-Transferase pi/*genetics/*metabolism;
Glutathione/*metabolism;
Genotype;
Female;
Case-Control Studies;
Asthma/*chemically induced/enzymology/*genetics;
Aspirin/*adverse effects;
Anti-Inflammatory Agents, Non-Steroidal/*adverse effects;
Alleles;
Adult
- From:The Korean Journal of Internal Medicine
2005;20(3):232-236
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: Glutathion S-transferase P1 (GSTP1), the abundant isoform of glutathione S-transferase in lung epithelium, plays an important role in cellular protection against oxidative stress and toxic foreign chemicals. GSTP1 (Ile105Val) polymorphism has been reported to be associated with asthma related phenotypes such as atopy and bronchial hyperresponsiveness. Therefore we investigated whether this polymorphism may be associated with the development of aspirin-intolerant asthma (AIA). METHODS: GSTP1 Ile105Val polymorphism was determined using a single based extension method in 88 AIA subjects and compared to 154 aspirin-tolerant asthma (ATA) subjects and 119 normal healthy controls (NC) recruited from the Korean population. RESULTS: No significant differences in allele and genotype frequencies of the GSTP1 Ilel105Val polymorphism were observed in the three groups (p> 0.05). However, minor G allele frequency of the GSTP1 Ilel105Val polymorphism in AIA group (16.5%) tended to be lower than in the NC group (20.6%). CONCLUSION: These results suggest a lack of association of the GSTPI Ilel105Val gene polymorphism with AIA phenotype in the Korean population [word count: 159].
