A Case of Uterine Cervical Cancer Presenting with Granulocytosis.
10.3904/kjim.2005.20.3.247
- Author:
Heui June AHN
1
;
Yeon Hee PARK
;
Yoon Hwan CHANG
;
Sun Hoo PARK
;
Min Suk KIM
;
Baek Yeol RYOO
;
Sung Hyun YANG
Author Information
1. Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea. yhpark@kcch.re.kr
- Publication Type:Case Report
- Keywords:
Leukocytosis;
Paraneoplastic syndrome;
Cervical cancer
- MeSH:
Uterine Neoplasms/complications/*diagnosis;
Uterine Cervical Neoplasms/complications/*diagnosis/physiopathology;
Paraneoplastic Syndromes/*etiology;
Middle Aged;
Leukocytosis/*etiology;
Humans;
Granulocytes/*pathology;
Female
- From:The Korean Journal of Internal Medicine
2005;20(3):247-250
- CountryRepublic of Korea
- Language:English
-
Abstract:
Granulocytosis occurs in 40% of patients with lung and gastrointestinal cancers, 20% of patients with breast cancer, 30% of patients with brain tumor and ovarian cancer and 10% of patients with renal cell carcinoma. Granulocytosis occurs because of production of G-CSF, GM-CSF and IL-6. Uterine cervical carcinoma with granulocytosis as a paraneoplastic syndrome, however, has been rarely reported. We recently witnessed a case of invasive squamous cell carcinoma of the uterine cervix with granulocytosis. Leukocytosis developed up to 69, 000/micro L, and then normalized after chemo-radiotherapy. There was no evidence of infection, tumor necrosis, glucocorticoid administration, or myeloproliferative disease by examination of a bone marrow aspirate when granulocytosis appeared. This phenomenon was probably associated with the secretion of hematopoietic growth factors such as G-CSF, GM-CSF and IL-6 by the tumor. We suggest that, like some other solid tumors, cervical cancer can present with granulocytosis as a paraneoplastic syndrome.
