Functional Magnetic Resonance Imaging Findings in Meares-Irlen Syndrome: A Pilot Sudy.
10.3341/kjo.2015.29.2.121
- Author:
Ji Hyun KIM
1
;
Hye Jin SEO
;
Suk Gyu HA
;
Seung Hyun KIM
Author Information
1. Department of Neurology, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Left temporal gyrus;
Magnetic resonance imaging;
Meares-Irlen syndrome
- MeSH:
Adolescent;
Adult;
Brain/*pathology/physiopathology;
Color Perception/*physiology;
Dyslexia/*diagnosis/physiopathology;
*Eyeglasses;
Female;
Humans;
Magnetic Resonance Imaging/*methods;
Male;
Perceptual Disorders/*diagnosis/physiopathology;
Pilot Projects;
Reading;
Syndrome;
Vision Disorders/*diagnosis/physiopathology;
Young Adult
- From:Korean Journal of Ophthalmology
2015;29(2):121-125
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: To investigate patterns of functional magnetic resonance imaging (fMRI) activation during sentence reading before and after wearing color-tinted lenses. METHODS: A total of 15 Meares-Irlen syndrome patients with a mean age of 23.4 years (range, 13 to 42 years) with no history of neurological or psychiatric disorders were scanned using a 3T MR scanner (Siemens, Tim-Trio, Germany). Each patient underwent two sessions of fMRI imaging (before and after MISViS color-tinted lens application). The fMRI paradigm included a block design of 20 seconds of rest (cross), 20 seconds of activation (sentence reading), and ten blocks (a total of 200 echo-planar image volumes) repeated for each session. Data preprocessing and analyses were performed using the SPM8 software package. RESULTS: The reading speed of patients improved more than 20% while wearing the selected lenses. When compared to the before-lens session, the after-lens session identified significant regions of activation in the left middle and superior temporal gyri (paired t-test; maximal z score, 5.38; Montreal Neurological Institute coordinate, -60 / -39 / 0; threshold at p < 0.05; corrected for multiple comparisons using family-wise error). No region of activation at the same threshold was found in the before-lens session as compared to the after-lens session. CONCLUSIONS: In the current study, we confirmed activation in the left middle and superior temporal gyri during sentence reading after wearing color-tinted lenses. These results could explain the effectiveness of color-tinted lenses in patients with Meares-Irlen syndrome.
