Human papillomavirus 18 as a poor prognostic factor in stage I-IIA cervical cancer following primary surgical treatment.
10.5468/ogs.2014.57.6.492
- Author:
Sun Hye YANG
1
;
Su Kyoung KONG
;
Seung Ho LEE
;
So Yi LIM
;
Chan Yong PARK
Author Information
1. Department of Obstetrics and Gynecology, Gachon University Gil Medical Center, Incheon, Korea. miracle627@gilhospital.com
- Publication Type:Original Article
- Keywords:
Genotype;
Human papillomavirus;
Prognosis;
Uterine cervical neoplasms
- MeSH:
Disease-Free Survival;
Genotype;
Human papillomavirus 16;
Human papillomavirus 18*;
Humans;
Medical Records;
Multivariate Analysis;
Prognosis;
Uterine Cervical Neoplasms*
- From:Obstetrics & Gynecology Science
2014;57(6):492-500
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: This study evaluates the effect of the specific human papillomavirus (HPV) genotype as a prognostic factor in stage I-IIA cervical cancer patients following primary surgical treatment. METHODS: The medical records of 116 cervical cancer patients treated with primary surgical treatment were reviewed. The HPV genotypes were categorized into following groups: negative and unclassified, HPV 16, HPV 18, and other high risk (HPV 31, 33, 35, 45, 51, 52, 56, and 58). RESULTS: Among the HPV genotypes, HPV 16 predominated (40.52%), followed by intermediate risk and unclassified (25%), HPV 18, 45, and 56 (17.24%) and negative (17.24%). In univariate analysis, HPV genotypes (P=0.03), parametrial spread (P=0.02), depth of invasion (DOI) (P<0.01) and lymph-vascular space invasion (P=0.02) were significantly associated with progression free survival (PFS). In multivariate analysis, HPV 18 (hazard ratio [HR], 5.2; 95% confidence interval [CI], 1.29 to 20.90; P=0.02) and > or =one half of DOI (HR, 5.4; 95% CI, 1.08 to 27.31; P=0.04) were significantly associated with PFS. HPV genotypes are not significantly associated with overall survival. CONCLUSION: HPV 18 was a poor prognostic factor for the PFS in stage I-IIA cervical cancer patients following primary surgical treatment. Careful long-term observation and regular exams are recommended for cervical cancer patients with HPV 18 compared to those with other HPV genotypes.
