Endoscopic Findings of Newly Developed Gastrointestinal Lesions after Eradication for Helicobacter pylori.
- Author:
Su Jin HONG
1
;
Bong Min KO
;
Jin Oh KIM
;
Joo Young CHO
;
Joon Seong LEE
;
Moon Sung LEE
;
Chan Sup SHIM
Author Information
1. Department of Internal Medicine, Soon Chun Hyang University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Newly developed lesions;
H. pylori;
Eradication
- MeSH:
Anti-Bacterial Agents;
Breath Tests;
Duodenal Ulcer;
Duodenitis;
Esophagitis, Peptic;
Follow-Up Studies;
Gastritis;
Helicobacter pylori*;
Helicobacter*;
Humans;
Incidence;
Peptic Ulcer;
Urease
- From:Korean Journal of Gastrointestinal Endoscopy
2002;24(1):6-10
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Eradication therapy for H. pylori infection is routinely used for treating patients with peptic ulcer disease. However, endoscopic findings after eradication therapy reveal some newly developed lesions. We have reviewed endoscopic findings to evaluate frequency and morphology of upper gastrointestinal lesions after eradication therapy for H. pylori. METHODS: We have studied 245 patients with peptic ulcer disease and H. pylori infection who had a successful eradication therapy. Endoscopic evaluation with rapid urease test, histology, and 13C-urea breath test was performed before eradication therapy and 6 weeks after. RESULTS: The incidence of newly developed lesions after eradication therapy was 14.3% at 6 weeks. The features of newly developed lesions after eradication therapy were as follows: 7 with reflux esophagitis (2.9%), 10 with acute gastritis (4.1%), 3 with duodenal ulcers (1.2%), 15 with erosive duodenitis (6.1%). These lesions were found during administration of H2 receptor blocker. No additional symptoms were found in these mucosal lesions. The development of these lesions was not related to duration of antibiotics. CONCLUSIONS: It is not rare to find some newly developed lesions after treatment of H. pylori infection. It is necessary to study pathogenesis of these lesions and have follow-up endoscopic examinations for a longer period of time.
